According to severity, sub-regional characteristics of aeolian desertification and natural and socio-economic environment, the Otindag Sandy Land region is divided into three sub-regions: slightly-moderately aeolian desertification developing sub-region to the north of the Otindag Sandy Land, seriously aeolian desertification developing sub-region in the Otindag Sandy Land and slightly aeolian desertification developing sub-region to the south of the Otindag Sandy Land. Five lower sub-regions have been divided for the reason. In order to realize the sustainable development in the Otindag Sandy Land region, aeolian desertification should be actively controlled according to regional aeolian desertification characteristics. Meanwhile the industrial structure should be adjusted and the intensive agricultural and livestock production should be implemented.