The eastern Xinjiang Basin is desperately short of water. Most rivers in the basin originate in the high eastern Tianshan, which has abundant precipitation and numerous alpine glaciers. Fieldwork conducted on three reference glaciers around Mt. Bogda in 1981 and 2009 suggests that they all strongly melt in summer, a process that has tended to accelerate in recent decades. Based on topographic maps from 1962 and 1972 and 2005/2006 satellite imagery, we investigated 203 glaciers near Mt. Bogda and 75 glaciers near Mt. Harlik. The results show that the surface area of the Mt. Bogda glaciers decreased by 21.6% (0.49% a?1) from 1962 to 2006. This was accompanied by a 181 m decrease in length and a 28% drop in ice volume. In the Mt. Harlik region, areal extent was reduced by 10.5% (0.32% a?1), length by 166 m, and volume by 14% between 1972 and 2005. South-facing glaciers lost more of their area than those that are north facing, yielding an areal loss of 25.3% and 16.9% for southern and northern slopes of Mt. Bogda, respectively, and 12.3% and 6.6% for the comparable slopes of Mt. Harlik. Glaciers smaller than 0.5 km2 in area experienced the strongest retreat, whereas glaciers larger than 2 km2 in area experienced gentle recession but may be the main contributors in the future to river runoff. Glacial ablation in eastern Xinjiang tends to be strong, and the water resources in this region are deteriorating. Also, a heavy reduction in the capacity of the local karez system, as well as a significant change in river runoff, can be related to glacial retreat. Combined, this will adversely affect the downstream city of Urumqi and the Turfan Basin.